References

Merging of lab and synchrotron datasets

(due to) V. A. Streltsov and A. van Donkelaar, CSIRO Health Sciences


SYNOPSIS: Structure datasets collected in the lab using PX50 optics demonstrate similar signal-noise ratio to data collected from the same specimens at the APS, permitting the merging of refinement data.

It is found that a lab crystallography system based on PX50 optics (RU3HR generator, PX50 optics, MAR & RaxisIV cameras) produces data of similar signal-noise ratio to that collected from the same specimens at the BIOCARS ID14 beamline at the Advanced Photon Source. This observation suggested the merging of the datasets to further improve the structure refinement statistics. Subsequent analysis of the merged datasets using DENZO demonstrated improved structure resolution compared to refinements of the independent datasets and the merged datasets were adopted for publication.

Reference: Lawrence, M. C., Borg, N. A., Streltsov, V. A., Pilling, P. A., Epa, V. C., Varghese, J. N., McKimm-Breschkin, J. L., Colman, P. M. (2004). Structure of the Haemagglutinin-neuraminidase from Human Parainfluenza Virus Type III. J. Mol. Biol. 335, 13431357.


(c) Copyright AXCO 2004

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