Protein and Macromolecular Crystallography Optics

Our X-ray focussing optical systems for protein crystallography are complete instruments designed to integrate seamlessly into popular macromolecular diffraction installations. They have been designed in collaboration with expert protein crystallographers to provide the optimum signal/noise ratio possible for data collection from all crystal sizes and popular ancilliary equipment configurations.

Your diffraction lab has two key tasks: To provide feedback on crystal quality to refine crystallisation and buffering factors etc. for further analysis, and then to produce the best structure data possible from the resulting crystals. For difficult crystals, you need quantitatively significant data from the first of these tasks to achieve meaningful results from the second, or provide the best possible crystals for synchrotron analysis. Crucially - a failure at the crystal-refinement stage can halt all progress toward achieving a molecular structure refinement. The unmatched signal/noise ratios demonstrated by our PX systems provide the best feedback information in this process, often salvaging otherwise unpromising development lines and minimising the number of crystal refinement cycles to achieve a structure. Our lab PX systems achieve equivalent signal/noise ratios to the best synchrotron PX beamlines - in some cases, better - producing the best data of ANY lab crystallography system. Our users report merging their lab and synchrotron datasets to improve their refinements.